The Collaborative Multi-Site Preclinical MRS Study (CoMP-MRS) is an international initiative uniting the rodent MRS community to perform the first large-scale, multi-site evaluation of MRS methodologies in rats and mice. Data from participating centers will be used to assess methodological variability and inform evidence-based best practices for preclinical MRS.
All datasets and automated pipelines will be available in a public, open-source repository. Ultimately, CoMP-MRS aims to identify the factors influencing spectral quality and neurochemical quantification, laying the groundwork for standardization and reproducibility in preclinical rodent MRS.